Author Archives: Dr. Thomas J. Waliser

About Dr. Thomas J. Waliser

Dr. Waliser is a gynecology specialist, performs minimally invasive surgery, and has been practicing medicine for over 22 years, primarily in the Scottsdale and Tucson areas. He graduated from the University of North Dakota School of Medicine & Health Sciences and completed his residency at St. Francis Hospital. Dr. Waliser is fellowship trained in Advanced Laparoscopy/Hysteroscopy and is board certified.

EndoCheck Clinical Trial

EndoCheck Clinical Trial

1 out of 10 women have endometriosis, a condition that can significantly impact a person’s quality of life. As with many conditions, the earlier the diagnosis, the better the treatment outcomes. Unfortunately, laparoscopy, an invasive procedure, is currently the only definitive way to diagnose endometriosis.

If you are facing a diagnostic laparoscopy due to your endometriosis-related symptoms, you may be eligible to participate in the EndoCheck clinical trial.

What Is Endometriosis?

Endometriosis is a chronic medical condition in which tissue similar to the lining of the uterus, called the endometrium, grows outside the uterus. Normally, the endometrium remains within the uterus and simply thickens throughout the month before being shed during menstruation. With endometriosis, this tissue grows in the pelvic cavity, on the surface of the uterus, and other organs, such as the ovaries, fallopian tubes, and tissues lining the pelvis.

While the endometrium is shed during menstruation and exits via the vaginal opening, the tissue outside of the uterus has no way to leave the body. Over time, this can cause inflammation, scarring, and painful adhesions.

What Is Endometriosis

Stages of Endometriosis

Endometriosis is classified into stages based on the severity, extent, and location of the disease.

The staging system used to classify endometriosis is the Revised American Society for Reproductive Medicine (rASRM), which categorizes endometriosis into four stages.

  • Stage 1 endometriosis is considered minimal, typically with minimal adhesions or scar tissue, and generally localized within the pelvic cavity.
  • Stage 2 endometriosis is mild, with numerous or slightly larger lesions, and involves both ovaries and other pelvic structures.
  • Stage 3 endometriosis is moderate, with multiple implants or lesions and deeper infiltrating lesions affecting the ovaries, fallopian tubes, or uterus. It may distort the anatomy and organ function.
  • Stage 4 endometriosis is severe and consists of extensive implants or lesions scattered throughout the pelvic cavity. It may extend to other parts of the body, such as the bowels or bladder.

Endometriosis at a more advanced stage does not always mean you will have more severe symptoms or pain. For example, some women with stage 4 endometriosis may have few or no symptoms, whereas others with stage 1 can experience severe symptoms.

Endometriosis Evaluation and Diagnosis

In order to diagnose endometriosis, a doctor will assess medical history, perform a pelvic exam, and run diagnostic tests.

During the review of your medical history, your doctor will ask about your symptoms, whether you have any risk factors associated with endometriosis, your periods and pelvic pain,  and whether you are experiencing infertility.

During the pelvic exam, your doctor will check for tenderness or pain. Afterward, your doctor may order imaging tests to examine the tissues around your pelvic area visually. Your doctor may make a “clinical diagnosis,” but this is not currently definitive without an invasive laparoscopy procedure.

Invasive laparoscopy procedure

A laparoscopy involves a small incision made in the abdomen near the belly button. The surgeon will insert a laparoscope – a long, thin tube equipped with a light and camera – through the incision before inflating the abdominal cavity with carbon dioxide gas. This will allow the surgeon to identify and examine any endometrial implants and even take a biopsy to send for laboratory analysis.

While laparoscopies are far less invasive than open-cavity surgery, they still involve some risk and recovery time. Fortunately, research is ongoing to demonstrate the effectiveness of a new diagnostic tool, the EndoCheck clinical test.

What Is EndoCheck?

If you are scheduled to undergo diagnostic laparoscopy to be evaluated for endometriosis, you may be eligible to access a non-invasive blood test called EndoCheck. This diagnostic test for endometriosis can help your gynecological professional diagnose endometriosis and guide decisions related to your ongoing care. Help us as we work to validate this procedure, potentially eliminating the need for laparoscopy in the future.

To be eligible to participate, you must:

  • Be able to provide written and informed consent or obtain the consent of an authorized representative or guardian.
  • Be a female aged 14 to 50 years old.
  • Be scheduled to undergo laparotomy or laparoscopy for suspected endometriosis.

How the EndoScope Clinical Trial Works

If you choose to participate, the endometriosis clinical trial will last approximately three months and include two visits to the Arizona Gynecology Consultants office. Upon arrival, you will complete an informed consent form along with an Endometriosis Health Profile Questionnaire and case report forms. Afterward, a blood sample will be collected. After your laparoscopy, and if you are confirmed to have endometriosis, you will complete the Endometriosis Health Profile Questionnaire again. We will compare the results of the blood study test to the pathology reports and surgical observations obtained during your surgery.

How the EndoScope Clinical Trial Works

Why Participate?

The goal of EndoCheck is to evaluate a new investigational test that may be able to detect endometriosis without the invasive procedure. Participating in this study allows you to be a part of changing the endometriosis prognosis journey and improving women’s quality of life. It may also reveal additional information about the medical roots of endometriosis.

Endometriosis Causes

The exact cause of endometriosis is not clear, but researchers have identified some promising theories.

Retrograde Menstruation

One theory suggests that during menstruation, some of the menstrual blood containing endometrial cells flows backward through the fallopian tubes into the pelvic cavity instead of leaving the body. These cells then implant and grow on the pelvic organs, causing endometriosis.

Coelomic Metaplasia

The theory of coelomic metaplasia suggests that certain cells lining the pelvic cavity can transform into endometrial-like tissue in response to hormonal or inflammatory signals. These transformed cells then create endometriosis lesions.

Embryonic Cell Changes

Some researchers speculate that endometriosis may result from embryonic cells that retain the ability to develop into various types of tissue, including endometrial-like tissue. These cells may become misplaced during embryonic development and create endometriosis lesions later in life.

Surgical Scar Complication

Surgical procedures involving the reproductive organs or pelvic cavity can cause tissue trauma, inflammation, and scarring, which may create an environment prime for the development of endometriosis. Inflammatory processes associated with surgical healing can promote the adhesion and proliferation of endometrial cells outside of the uterus.

Immune System Condition

A potential problem with the immune system is that the body may not recognize and destroy endometriosis tissue since it is produced within the body. Endometriosis has also been associated with systemic lupus erythematosus (SLE) and Hashimoto’s thyroiditis.

Genetics

Endometriosis may affect some people more often due to a genetic trait passed down in their families. Women with a close relative who has endometriosis, such as a mother, sister, or daughter, are at an increased risk of developing the condition themselves compared to those with no family history.

Endometriosis Symptoms

The main symptom of endometriosis is pelvic pain, often linked with menstruation. This pain can be a dull ache, cramping, or even sharp stabbing sensations, depending on the person. It may even worsen over time.

Endometriosis Symptoms

Other common symptoms include:

Painful Periods

Painful periods, medically known as dysmenorrhea, are a common symptom of endometriosis. This pain can be debilitating and may interfere with daily activities and quality of life. Some people with endometriosis experience deep pelvic pain or pressure during menstruation from the presence of endometrial implants or lesions near the cervix, uterus, ovaries, or rectum. Endometriosis pain can also impact the lower back, thighs, or buttocks.

Dyspareunia

Dyspareunia occurs when endometrial or scar tissue in the pelvic region causes pain or discomfort during sexual intercourse. This can lead to difficulties with intimacy and potential strain on relationships.

Infertility

Endometriosis is the leading cause of infertility in women, affecting up to 30-50% of women who experience infertility. The disease can distort pelvic anatomy, interfere with ovulation, and damage eggs and sperm.  Alterations in the endometrial lining may also affect embryo implantation and early pregnancy development, along with changes in hormone levels, inflammation, and immune system dysfunction.

Gastrointestinal Symptoms

Endometrial growths on pelvic organs and bowels can lead to bloating, constipation, diarrhea, abdominal cramping, and nausea and vomiting. Endometrial growths or adhesions near the rectum or sigmoid colon can cause discomfort or pain during bowel movements. These can all worsen during menstruation.

Fatigue

Chronic pain and discomfort, pain management, coping with symptoms, and disrupted sleep patterns can contribute to fatigue and exhaustion. This is an often overlooked symptom, but it can significantly impact a person’s quality of life.

Urinary Symptoms

Some women may experience endometrial growths that affect the urinary tract. Endometriosis can cause interstitial cystitis (IC), which is a chronic condition that causes bladder pain, urinary urgency, frequency, and discomfort. Women with endometriosis may also be at an increased risk of urinary tract infections because of urinary retention, inflammation, or obstruction caused by endometrial growths or adhesions.

Other Symptoms

Endometriosis can also cause back pain, leg pain, heavy menstrual bleeding, and irregular menstrual cycles. The extent and severity of these symptoms will vary among each individual, and some women do not have any symptoms. As mentioned, having a more advanced stage of endometriosis, such as stage 4, does not mean more severe symptoms or pain.

Many symptoms may not be typically associated with endometriosis, which can complicate diagnosis and treatment. People may think they have irritable bowel syndrome (IBS) or uterine fibroids, but diagnostics reveal endometriosis.

Treatment Options

While endometriosis currently has no cure, there are treatment options available to help manage pain, slow tissue and implant growth, and help with potential infertility.

The first line of treatment is medication, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen, combined (estrogen-progestin) contraceptives, progestin, gonadotrophin-releasing hormone (GnRH) agonists, danazol, or aromatase inhibitors are the most commonly prescribed.

Treatment Options

If medications are not working, surgery may be a choice. Surgeries may be used to remove scar tissue and endometrial implants or hysterectomy with or without bilateral scalping-oophorectomy. This involves the removal of the uterus while leaving or removing the ovaries and fallopian tubes.

What are the Risk Factors for Endometriosis?

It is possible to develop endometriosis later in life, but it usually manifests during a woman’s reproductive years.

Factors that raise the risk of endometriosis include:

  • Starting your period at an early age
  • Starting menopause at an older age
  • An abnormal uterus
  • Heavy periods that are longer than seven days
  • A menstrual cycle that is shorter than 27 days
  • Higher levels of estrogen in your body or greater exposure to estrogen than your body normally produces
  • Low body mass index
  • You have a genetic connection to family members with endometriosis.

Additionally, any health condition that prevents menstrual blood from leaving your body can increase your risk of endometriosis.

Help Reduce the Impact of Endometriosis

Endometriosis can significantly impact a woman’s life, including physical health, emotional well-being, relationships, work, and social activities, due to severe pain, fatigue, infertility, anxiety, and depression. Addressing endometriosis will help empower those experiencing it and improve women’s sexual and reproductive health, quality of life, and well-being. First, however, it’s crucial to make the process of diagnosing endometriosis as painless and stress-free as possible. We urge you to consider participating in the EndoCheck clinical trial and potentially help minimize the impact of endometriosis on others.

If you’re interested, please contact your surgeon at Arizona Gynecology Consultants for further information.

 


Resources:

  1. Endometriosis. (2021, February). Www.acog.org. https://www.acog.org/womens-health/faqs/endometriosis
  2. World Health Organization. (2023, March 24). Endometriosis. World Health Organization; World Health Organization. https://www.who.int/news-room/fact-sheets/detail/endometriosis
  3. ?Matsuura, K., Ohtake, H., Katabuchi, H., & Okamura, H. (1999). Coelomic metaplasia theory of endometriosis: evidence from in vivo studies and an in vitro experimental model. Gynecologic and Obstetric Investigation, 47 Suppl 1, 18–20; discussion 20-2. https://doi.org/10.1159/000052855
  4. ?John Hopkins Medicine. (2024). Endometriosis. John Hopkins Medicine. https://www.hopkinsmedicine.org/health/conditions-and-diseases/endometriosis
  5. ?Endometriosis. (n.d.). Yale Medicine. https://www.yalemedicine.org/conditions/endometriosis
  6. ?Mayo Clinic. (2023, October 12). Endometriosis – Symptoms and Causes. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/endometriosis/symptoms-causes/syc-20354656
  7. ?Bafort, C., Beebeejaun, Y., Tomassetti, C., Bosteels, J., & Duffy, J. M. (2020). Laparoscopic surgery for endometriosis. Cochrane Database of Systematic Reviews, 10(10). https://doi.org/10.1002/14651858.cd011031.pub3
  8. ?Endometriosis: Does It Cause Infertility? (n.d.). Www.reproductivefacts.org. https://www.reproductivefacts.org/news-and-publications/fact-sheets-and-infographics/endometriosis-does-it-cause-infertility/
  9. ?American Society for Reproductive. (1997). Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertility and Sterility, 67(5), 817–821. https://doi.org/10.1016/s0015-0282(97)81391-x
What is female sterilization?

What You Need to Know About Female Sterilization

Since the early days of birth control, science has come a long way in giving individuals valid choices surrounding reproductive health. Whether a woman would like to have a child or avoid pregnancy, we have many ways to help her achieve her goals. One such method of avoiding pregnancy is female sterilization. Though it is not often discussed as a starting point, female sterilization is a viable option for preventing pregnancy. In fact, it is one of the most reliable forms of birth control on the market today.

What Is Female Sterilization?

Female sterilization is the process of blocking the fallopian tubes to keep sperm from meeting with an egg and implanting inside the uterine lining. Normally, when an egg does travel out of the ovaries and into the fallopian tubes, it can be fertilized by any incoming sperm. With the fallopian tubes blocked by a sterilization procedure, sperm cannot find their way to an egg, and fertilization cannot occur. In this way, sterilization prevents pregnancy. This procedure is permanent.

Types of Sterilization

There are several types of female sterilization. Each of them has different benefits and may be right depending on the patient’s unique needs.

Tubal Ligation

Tubal ligation is most similar to the process described above. In this procedure, a doctor will cut or close a fallopian tube laparoscopically, meaning that the process is minimally invasive. In some situations, the doctor may even remove a part of the fallopian tube during a tubal ligation.

Bilateral Salpingectomy

In this process, a doctor entirely removes the fallopian tube. Bilateral Salpingectomy poses no risk of ectopic pregnancy or fallopian tube regrowth.

Female Sterilization Following Pregnancy

Because sterilization is an effective family planning method, many individuals opt to undergo the procedure following the birth of a child. Many families know when they are finished having more children, and immediately post-birth is a simple time to undergo the procedure. Rather than being done laparoscopically, a doctor can perform sterilization through the vagina while the birth canal is still dilated. Cesarean births also present a convenient time for the procedure.

Is Female Sterilization Painful?

It is not considered a painful procedure. A patient may have mild pain at the incision site, as well as cramping in the abdominal area as the body adjusts. This is usually very minor pain, and it passes quickly.

How Long Does It Take to Recover From Female Sterilization?

Recovering From Female SterilizationFemale sterilization is usually an outpatient procedure. After the doctor is finished, the patient will be monitored regularly for a few hours. This is simply to verify that nothing major has gone wrong and that the body is recovering well. After that, it is normal for the patient to be discharged. Rest is recommended for the first week, and the doctor will likely schedule a follow-up around 7 days later. The doctor can also give specific instructions on care and recovery time based on the individual patient’s situation.

What Are the Side Effects of Female Sterilization?

The primary and most obvious purpose of female sterilization is to prevent pregnancy. However, as with any medical procedure, there may be unintended side effects of the procedure. Bleeding is possible, both internally and vaginally.

It is possible for an infection to occur as well. However, this is rare. Patients should always speak with their doctor about any procedures and be sure to know about side effects or risks associated with them before making any decisions.

Sex After Sterilization

After the sterilization procedure, patients can return to their normal sex lives when it feels comfortable to do so. When a patient sees their doctor for the procedure follow-up, they can ask for details about what the doctor does and does not recommend in the way of sexual activity. Once a patient is healed, sex drive and sexual activity often return to normal.

It is important to use alternative contraception for three months following sterilization. This is to ensure that the internal wound is healed and able to effectively prevent pregnancy. Pregnancy, especially ectopic pregnancy, can occur in the three months following the procedure.

Pregnancy After Sterilization

Sterilization is nearly 100% effective at preventing pregnancy. However, there is a very slim chance that a pregnancy will occur following sterilization.

Because the fallopian tubes are cut, blocked, or otherwise compromised, pregnancies that occur after sterilization are ectopic. Ectopic pregnancies are pregnancies that occur outside of the uterus. The uterus is the only area in which a fertilized egg can develop. Ectopic pregnancies, therefore, do not make it to term. However, they can be extremely painful and can damage surrounding organs if not properly addressed.

Does Sterilization Protect Against STDs?

Many people use birth control such as condoms and dental dams to protect against sexually transmitted infections or diseases. Sterilization does not replace these methods in this effort. If a patient has multiple partners, has not been recently tested, or has a partner with a known STD, it is important to continue to use physical barriers such as condoms to prevent STD transmission. Sterilization will only protect against pregnancy, not STDs.

Sterilization and Menstrual Cycles

It is essential to note that sterilization is not intended to alter the menstrual cycle. In fact, your cycle will likely remain the same after the procedure. Many people use birth control options such as the pill and an IUD to manage painful, heavy, or irregular periods. These options are often effective because they contain hormones that alter the menstrual process. Sterilization is not this way. It will only prevent pregnancy — it will not alter menstruation.

Is Sterilization Right for Me?

Is Sterilization Right for Me?As mentioned, sterilization is a permanent procedure that prevents pregnancy at a nearly 100% rate. Though the procedure can technically be reversed, it is not always successful. Reversals are not guaranteed, and not even recommended in many cases. If a patient is considering sterilization, it should be assumed that the effects will be permanent.

These are some key questions a patient should ask themselves if sterilization is a possible option:

Is There Any Chance I’ll Want to Get Pregnant in the Future?

Remaining childless is a very valid option for many people, and many know from a young age that they do not want to have children. However, sometimes patients have only recently come to the conclusion. In these situations, alternatives might be better until the decision feels like a permanent one.

Is My Decision to Sterilize a Response to a Temporary Situation?

Sometimes, patients believe that sterilization is the right choice because they are battling a difficult situation. For example, a difficult patch in a marriage, sexual issues, economic hardship, or illness can prompt an individual to want to avoid pregnancy. However, no matter how bleak a situation may seem, none of the above will necessarily last forever. It is very possible that the situation prompting the decision will end and the individual may want to have a child.

Though, of course, this is not always the case, it is a strong possibility. If a patient is exploring sterilization in response to hardship, another birth control option may better suit their needs.

Do I Feel Pressured to Get Sterilized?

No patient should feel pressured to undergo a procedure unless it is medically necessary to keep them alive. If friends, family, a partner or partners, or anyone else is pressuring the patient to undergo sterilization, it is not wise to do so. If this is the case, it is important for the patient to have an open and honest conversation with their doctor about the circumstances. Often, there are other options that would be more appropriate.

What Are the Benefits of Sterilization Over Other Options?

It is essential to be sure that sterilization has unique advantages over other options. It is important to understand all of the options and ensure that sterilization has benefits that other reproductive health choices do not. Some patients find that less permanent options deliver similar results and offer them enhanced freedom.

Alternative Options

A large part of the sterilization process is exploring options to make sure that sterilization is right for the patient. Many doctors will not agree to the procedure until a basic understanding of reproductive options has been established. Sterilization is permanent, and most doctors want to ensure that their patients do not regret getting a life-changing procedure.

IUD

An IUD, or intrauterine device, is a small plastic or metal t-shaped object inserted into the uterus through the vagina. A doctor can do this in an outpatient procedure at a clinic, and recovery is fairly minimal. Most people experience minor pain or cramping for the first few days after the device is inserted.

There are two types of IUDs, copper and hormonal. The hormonal option releases hormones similar to the birth control pill that further aid in contraception. The copper IUD does not contain hormones but keeps an embryo from implanting in the uterine wall.

An IUD is a major alternative for those interested in the efficacy of sterilization, but who are not sure about the permanence. IUDs remain in the uterus for 3-12 years or until removed, depending on the brand and type. Once it is removed, your fertility returns.

Though sterilization is slightly more effective than an IUD, IUDs are a less permanent option for those who are going through a temporary situation, or who may want to get pregnant in the future.

Vasectomy

For those in monogamous partnerships concerned with getting pregnant, vasectomies are a viable alternative to female sterilization. Vasectomies are for male partners and are much easier to reverse, meaning that you can change your mind later on and expect to successfully conceive. Vasectomies are less invasive as well and often have a shorter recovery period.

Talking to a Doctor About Female Sterilization

Talking to a Doctor About Female SterilizationHere at Arizona Gynecology Consultants, we believe that the power is in the hands of the patient. Our job is to inform patients of their options, any side effects, any dangers, and empower them to make the decision that is right for them. Though many ‘professionals’ will assume that a patient will change their mind about childlessness, we stay away from swaying our patients in any particular direction, and simply supply them with facts. Ultimately, the power is always in the patient’s hands.

For more information on female sterilization, or to talk to a medical professional about options, contact us today.